Structure of atpase
WebMar 13, 2024 · Vesicular- or vacuolar-type adenosine triphosphatases (V-ATPases) are ATP-hydrolysis–driven proton pumps that are essential for acidification of endosomes, … All of the ATPases share a common basic structure. Each rotary ATPase is composed of two major components: F 0 /A 0 /V 0 and F 1 /A 1 /V 1. They are connected by 1-3 stalks to maintain stability, control rotation, and prevent them from rotating in the other direction. One stalk is utilized to transmit … See more ATPases (EC 3.6.1.3, Adenosine 5'-TriPhosphatase, adenylpyrophosphatase, ATP monophosphatase, triphosphatase, SV40 T-antigen, ATP hydrolase, complex V (mitochondrial electron transport), (Ca + Mg )-ATPase, HCO3 … See more The Walker motifs are a telltale protein sequence motif for nucleotide binding and hydrolysis. Beyond this broad function, the Walker motifs can … See more The ATP synthase of mitochondria and chloroplasts is an anabolic enzyme that harnesses the energy of a transmembrane proton gradient … See more • ATP synthase • ATP synthase alpha/beta subunits • AAA proteins See more Transmembrane ATPases import metabolites necessary for cell metabolism and export toxins, wastes, and solutes that can hinder cellular processes. An important example … See more ATPase (also called F0F1-ATP Synthase) is a charge-transferring complex that catalyzes ATP to perform ATP synthesis by moving ions … See more There are different types of ATPases, which can differ in function (ATP synthesis and/or hydrolysis), structure (F-, V- and A-ATPases contain rotary motors) and in the type of … See more
Structure of atpase
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WebHere, we derive a structural model of the ATPase assembly using a combination of X-ray crystallography, small-angle X-ray scattering, molecular modeling, and biochemical data. … WebSep 1, 2000 · Key features of the structure are two distinct NBSs, each composed of residues from both the A1 and A2 halves of the protein, a novel metalloid-binding site that allosterically modulates the ATPase activity and two signal transduction elements that physically connect the allosteric and catalytic sites. Results Overall structure
WebMar 29, 2024 · The widespread P-type ATPases, which are featured with a phosphorylated intermediate during the transport cycle (P stands for phosphorylation), catalyze the transport of ions, phospholipids, polyamines, or transmembrane (TM) helices by utilizing the energy of ATP hydrolysis (7–10).The human genome encodes a total of 14 P4 ATPase members, … WebThe carboxyl half of the molecule is connected to the amino-terminal portion by a highly conserved “hinge” region. Adjacent to the carboxy-terminal end of the molecule is the …
WebJun 20, 2024 · The structure of the chloroplast F 1 F o complex explains how ATPase activity is turned off at night by a redox switch. Structures of mitochondrial ATP synthase dimers indicate how they shape the inner membrane cristae. The new cryo-EM structures complete our picture of the ATP synthases and reveal the unique mechanism by which … WebApr 5, 2024 · Semantic Scholar extracted view of "Computational characteristics of the structure-activity relationship of inhibitors targeting Pks13-TE domain." by Shizun Wang et al. ... Virtual screening was applied to select candidate inhibitors of the M. tuberculosis DNA gyrase ATPase activity from the Specs compound library, finding compounds G24 and …
Web22 hours ago · The structure was determined by molecular replacement in PHASER using the structure of HIM-3 (PDB ID 4TRK) as a search model. An initial model was rebuilt in …
WebAug 1, 2001 · The hydrated F 1-ATPase (Fig.1, Fig.5) is a compact molecule with a headpiece of approximately 108Å from top to bottom and 110Å wide. However, the overall … chess olympiad 2021WebJul 6, 2015 · The ATPase machine powering this process is the strongest known biological motor. However, the structure and mechanism of this motor are unknown. Here, we derive a structural model of the ATPase assembly using a combination of X-ray crystallography, small-angle X-ray scattering, molecular modeling, and biochemical data. chess olympiad 2022 leaderboardWebApr 1, 2004 · The first X-ray structure of a P-type ATPase defines the four principal domains, and highlights a surprisingly long distance between the ion-translocation site … chess olympiad 2022 chennai placeWebApr 8, 2024 · Structure The Na+-K+ pump is a P-type ATPase that resembles the H+-K+-ATPase and the sarco (endo) plasmic reticulum Ca2+-ATPase in structure. The sodium-potassium pump is a transmembrane protein that is divided into three subunits. The 3 subunits are: α-Subunit- It is the largest subunit that contains the binding sites for Na+, K+, … chess olympiad 2022 chennai locationWebAug 23, 2024 · Our structure of the intact V/A-type enzyme reveals how V o and V 1 domains are coupled and serves as a reference for the entire V-type ATPase family. The additional … chess olympiad 2022 final standingsWebNov 8, 2024 · The S. cerevisiae plasma membrane H + -ATPase, Pma1, is a P3A-type ATPase and the primary protein component of the membrane compartment of Pma1 … good morning office thursdayWebSep 14, 2024 · ATP is found in all known forms of life, where it provides energy to drive muscle contraction, impulse propagation and chemical synthesis. Despite ATP’s central … good morning old norse